Fresh News!!! Cellular rejuvenation protects neurons from inflammation-mediated cell death
Multiple sclerosis (MS) might be amenable to treatment via epigenetic age reversal . The paper (�Cellular rejuvenation protects neurons from inflammation-mediated cell death� Cell Reports, 2025) suggests MS accelerates neuronal aging & its reversal via OSK-reprogramming preserves vision in an MS mouse model, suggesting new strategies for treating MS & potentially other neurological diseases. Delivering OSK factors (Oct4, Sox2, Klf4) via a domesticated adeno-associated virus (AAV2) reprogrammed neurons � ostensibly to a younger epigenetic state � thereby reducing cell death & preserving visual function in the MS model. These exciting new findings, led by the Fourier lab, are supportive of work published with Bruce Ksander�s lab @harvardmed on the acceleration of aging due to injury the reversal of blindness in a mouse model of glaucoma & old mice by rejuvenating RGC nerves via OSK (Lu et al., Nature, 2020). Dr. David Sinclair says they look forward to testing chemical reprogramming factors and seeing the results of human clinical trials using OSK to reprogram RGCs, set to start later this year to treat blindness at Life Biosciences.
Do We understand Aging? The 9 Cuases of Aging
Science found a consensus in 2013 (The Hallmarks of Aging, Cell 2013). Let's understand it in plain words
| Causes | Scientific Definition |
|---|---|
| 1.The DNA gets damaged | "Genomic Instability" |
| 2.The DNA length shortens from the extremes (telomeres) | "Telomere Attrition","Telomere Clock" |
| 3.The labels to read the DNA get messy | "Epigenetic Alterations" |
| 4.Cells start piling up cell residues | "Loss of Proteostasis" |
| 5.The little machines that produce Energy in the cell die | "Mitochondrial Dysfunction" |
| 6. Your body starts piling up zombie cells instead of killing them for good | "Cellular Senescence" |
| 7. All the cells come from stem cells, and even they start dying | "Stem Cell Exhaustion" |
| 8. The communication between cells gets messy | "Altered Intercellular Communication" |
| 9.The cells forget how to nurture themselves | "Deregulated Nutrient Sensing" |